Cell Therapy in the treatment of knee osteoarthritis

Cell Therapy in the treatment of knee osteoarthritis

The medical Journal Transplantation, the official journal of the transplantation society, featured on its cover of June 2013 the article published by ITRT research team addressing the treatment of osteoarthritis of the knee with stem cells cultured at the Institute of Genetics and Molecular Biology of Valladolid (IBGM).

The scientific journal "Transplantation", the official journal of the American Society of Transplantation, devoted the entire front cover of their June 2013 issue to the article published by the ITRT research team on treatment of osteoarthritis of the knee with stem cells cultured at the Institute for Biology and Molecular Genetics in Valladolid. (Article abstract translated)

The two-year follow-up results were published in the same journal in June 2014, confirming the longevity of the treatment.BACKGROUND

Osteoarthritis is the most prevalent joint disease and a frequent cause of joint pain, functional loss, and disability. Osteoarthritis often becomes chronic, and conventional treatments have demonstrated only modest clinical benefits without lesion reversal. Cell-based therapies have shown encouraging results in both animal studies and a few human case reports. We designed a pilot study to assess the feasibility and safety of osteoarthritis treatment with mesenchymal stromal cells (MSCs) in humans and to obtain early efficacy information for this treatment.

METHODS
Twelve patients with chronic knee pain unresponsive to conservative treatments and radiologic evidence of osteoarthritis were treated with autologous expanded bone marrow MSCs by intra-articular injection (40×10 cells). Clinical outcomes were followed for 1 year and included evaluations of pain, disability, and quality of life. Articular cartilage quality was assessed by quantitative magnetic resonance imaging T2 mapping.

RESULTS
Feasibility and safety were confirmed, and strong indications of clinical efficacy were identified. Patients exhibited rapid and progressive improvement of algofunctional indices that approached 65% to 78% by 1 year. This outcome compares favorably with the results of conventional treatments. Additionally, quantification of cartilage quality by T2 relaxation measurements demonstrated a highly significant decrease of poor cartilage areas (on average, 27%), with improvement of cartilage quality in 11 of the 12 patients.

CONCLUSIONS
MSC therapy may be a valid alternative treatment for chronic knee osteoarthritis. The intervention is simple, does not require hospitalization or surgery, provides pain relief, and significantly improves cartilage quality.

You can look up the original abstract here

Bibliographical reference of 2-year follow-up results:
Orozco, Lluís; Munar, Anna; Soler, Robert; Alberca, Mercedes; Soler, Francesc; Huguet, Marina; Sentís, Joan; Sánchez, Ana; García-Sancho, Javier.
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells: Two-Year Follow-up Results. 

 

Transplantation.15 June 2014 - Volume 97 - Issue 11. (Letter)