Lumbar intervertebral disc regeneration with MSV*

stem cells regeneration of the lumbar intervertebral disk - ITRT
ITRT Photo: Intra-disc injection of mesenchymal progenitor cells (adult stem cells)
 
In 2007, the ITRT signed an agreement with Instituto de Salud Carlos III, an independent body now affiliated to the Ministry of Finance, which allowed the conducting of a clinical trial to assess the regenerative capacity of the lumbar intervertebral disc following percutaneous implantation of MSV, which are bone marrow stem cells, selected and cultured at Instituto de Biología y Genética Molecular (IBGM) [Institute of Biology and Molecular Genetics] in Valladolid.
The trial, approved by the Agencia Española de Medicamentos y Productos Sanitarios AEMPS [Spanish Agency for Medicines and Medical Devices], was conducted within the framework of the “Advanced Therapies and Regenerative Medicine Plan” implemented by the Council of Ministers in October 2007.

The trial included 10 patients with lumbar disc problems who met set criteria. They made good progress clinically with no complications. Nine patients experienced significant improvement in their level of pain and five showed signs of regeneration in terms of increased disc height and hydration.

The results of the trial were published in scientific journal "Transplantation", the official journal of the American Society of Transplantation.

The AEMPS continues to regularly authorise the research team to treat new patients on a personalised basis. Up to January 2013, a total of 83 patients had been treated and were showing similar signs of progress.