Pilot Study of the Electrode-Myocardium Interface in Permanent Cardiac Pacing after Local Application of Platelet-Rich Plasma.
Objectives
This ITRT research line aims to generate scientific evidence of the anti-inflammatory and anti-fibrotic effects of LP-PRP at the electrode-myocardium interface when applied at the anchoring point of epicardial electrodes.
Methodology
The studies, conducted in canine and porcine models, were coordinated by Dr. Joaquim Delclós, a cardiac surgeon at Hospital Ntra. Sra. del Mar in Barcelona, with the participation of the Veterinary Clinical Hospital and the Faculty of Veterinary Medicine at the Universitat Autònoma de Barcelona.
Two porcines and two canines were treated. Histological analysis was performed on the electrode-myocardium interface of epicardial electrodes impregnated with or without PRP.
Results
The results evidenced the potent anti-inflammatory effect of leukocyte-poor PRP; fibrosis around the anchoring site was reduced by half compared to cases where PRP was not applied.
Conclusions
The translational interest of these studies lies in the possibility of improving the efficacy and considerably extending the lifespan of epicardial pacemakers used in pediatrics.
Technical Sheet [PORCINE STUDY]
Status: Completed, Published
Promoter: GUIDANT CORPORATION CARDIAC RHYTHM MANAGEMENT GUIDANT, S.A.
IACUC / Ethics Committee: Veterinary Clinical Hospital (UAB)
Investigators: J. Delclòs, C. Díaz Bertrana, L. Rodríguez, R. Soler Rich, I. Durall, M. Pumarola, Ll. Orozco
Entities: Cardiac Surgery Service, Hospital Ntra. Sra. del Mar (Barcelona); Veterinary Clinical Hospital (UAB); Center for Tissues and Cellular Therapy; ITRT-Teknon Medical Center; Faculty of Veterinary Medicine (UAB)
Research Grant: Fundación Universal
Technical Sheet [CANINE STUDY]
Status: Completed, Published
Promoter: GUIDANT CORPORATION CARDIAC RHYTHM MANAGEMENT GUIDANT, S.A.
IACUC / Ethics Committee: Veterinary Clinical Hospital (UAB)
Investigators: J. Delclòs, C. Díaz Bertrana, L. Rodríguez, R. Soler Rich, I. Durall, M. Pumarola, Ll. Orozco
Entities:Cardiac Surgery Service, Hospital Ntra. Sra. del Mar (Barcelona); Veterinary Clinical Hospital (UAB); Center for Tissues and Cellular Therapy; ITRT-Teknon Medical Center; Faculty of Veterinary Medicine (UB)
Research Grant: Fundación Universal
Scientific Collaboration: S. Vidal, F. Vidal.
